Z-83

Z-83™ is a unique nootropic and energy-enhancing supplement designed to support and enhance both cognitive and physical function, endurance and alertness. The combination of Zembrin® and Amatea® Max reduces the reliance on caffeine and provides a novel, bioactive formulation that is experiential and well-tolerated.

This exclusive composition leverages the unique bioactivity profile of two distinctive, unmatched botanical extracts, coupled with green coffee bean-derived caffeine, delivering complementary support to exercise, executive, academic, and recreational activities. Suitable for vegans.* 

Clinical Applications 

• Delivers an exclusive consortium of nootropic + arousal-promoting bioactives*
• Caffeine from purely botanical sources—not synthetic 
• Provides an array of phytochemicals to complement and augment caffeine efficacy*
• Lower strength caffeine content per capsule provides greater dose flexibility* 

Discussion 

Stimulant products are often anchored to and limited by the amount of caffeine present: too little and the effects are minimal to imperceptible; too much and the adverse sympathomimetic effects (excessive/intolerable spikes of adrenaline in response to caffeine and similar stimulants) can be crippling and intolerable.

Z-83™ 

Is a scientifically-engineered nootropic and arousal support supplement, a fusion of two unmatched, non-duplicable botanical extracts (Amatea® Max and Zembrin®) with certified organic green coffee bean-extracted caffeine. This exclusive blend is designed to offer a reproducible and experiential enhancement of physical and cognitive function, and support mood, at rest and after exercise, suggesting a role in a variety of lifestyle situations and events. 

Amatea® Max

Is a caffeine-containing extract produced from guayusa, a species of naturally caffeinated holly tree native to the Amazon rainforest. Guayusa lacks the bitter, astringent tannins (large polyphenols) yet delivers a distinctive polyphenolic antioxidant profile with chlorogenic acids (similar to coffee plants) and select flavonoids. [South America provenance] 

Caffeine

Green coffee beans (from organic Green coffee beans) are prepared with a targeted extraction process in a sustainable, green chemistry manner, which also removes naturally occurring mycotoxins (toxins from mold). The result is a truly green, clean caffeine source. [Canada provenance] 

Zembrin®

Is a unique extract of Sceletium tortuosum, a succulent plant native to South Africa. It is free of any known stimulants and has been shown to support acute, occasional fluctuations in mood and anxiety, and reinforce healthy sleep (1,2). Additional pilot studies have revealed its impact upon reaction time under mental/cognitive load, and support of mood states following exercise (3,4). [South Africa provenance] 

1. Reay J, et al. Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers. Hum Psychopharmacol Clin Exp 2020;35:1–7. 
2. Chiu S, et al. Proof-of-concept randomized controlled study of cognition effects of the proprietary extract Sceletium tortuosum (Zembrin) targeting phosphodiesterase-4 in cognitively healthy subjects: Implications for Alzheimer’s dementia. Evid-Based Complement Altern Med 2014:682014. 
3. Hoffman JR, et al. Ergogenic effects of 8 Days of Sceletium tortuosum supplementation on mood, visual tracking, and reaction in recreationally trained men and women. J Strength Cond Res 2020;34:2476–2481. 
4. Berry AR, et al. Effects of Zembrin® (Sceletium tortuosum) supplementation on mood, soreness, and performance following unaccustomed resistance exercise: A pilot study. Nutraceuticals 2021;1:2-11.